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The phase II obesity study of retatrutide also included a MASH substudy to assess its effects on the amount of liver fat

Mean body weight reduction from baseline was 15.8% with semaglutide 2.4 mg versus 6.4% with liraglutide 3.0 mg at 68 weeks

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While animal studies provide robust data, human pharmacokinetic profiles are less defined, with ongoing research exploring its full pharmacological behavior

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