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Abbreviations DN: Diabetic neuropathy DPN: Diabetic peripheral neuropathy NLRP3: Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 TCA: Tricyclic antidepressants SNRIs: Serotonin and norepinephrine reuptake inhibitors AGEs: Advanced glycation end-products PKC: Protein kinase C ROS: Reactive oxygen species ASC: Apoptosis-associated speck-like protein TLRs: Toll-like receptors DAMPs: Damage-associated molecular patterns PAMPs: Pathogen-associated molecular patterns TRX: Thioredoxin-interacting protein GSDMD: Gasdermin D AMPK: Adenosine 5- monophosphate-activated protein kinase TET2: Tet methyl-cytosine dioxygenase 2 COX: Cyclooxygenase LOX: Lipoxygenase iNOS: Inducible nitric oxide synthase STZ: Streptozotocin MNCV: Motor nerve conduction velocity SNCV: Sensory nerve conduction velocity NF-B: Nuclear factor-kappa B JNK: Jun N-terminal Kinase NLCs: Nanostructured lipid carriers SLN: Solid lipid nanoparticles References Abo-Salem OM (2014) Kaempferol attenuates the development of diabetic neuropathic pain in mice: possible anti-inflammatory and anti-oxidant mechanisms