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However, understanding the link between the receptor pharmacology that we observed in our study and real-world performance of each agonist is hampered by the different dosing and administration schedules (10 g twice daily for exenatide, or weekly as a sustained release preparation, compared to 20 g once daily for lixisenatide)

They work through several important mechanisms: They increase insulin release from the pancreas when blood glucose is high They reduce excess glucose release from the liver They slow stomach emptying, helping prevent sharp glucose spikes after meals They increase feelings of fullness, often reducing appetite Because these effects depend on blood glucose levels, GLP-1 medications on their own carry a very low risk of causing low blood sugar (hypoglycaemia)

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