Researchers attribute this to improved neuromuscular efficiency and increased glycogen storage (IGF-1 enhances GLUT4 translocation, driving more glucose into muscle cells)
Other medical reasons for pausing treatment include severe gastrointestinal adverse effects that don't improve with dose reduction or supportive measures, acute kidney injury related to dehydration from gastrointestinal side effects, severe hypoglycemia (particularly when combined with insulin or sulfonylureas), and worsening diabetic retinopathy
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Research consistently shows that higher protein intake helps: Preserve lean muscle mass Increase satiety Improve recovery Support metabolism Reduce cravings The National Institute of Diabetes and Kidney Diseases (NIDDK), part of the National Institutes of Health, emphasizes the importance of preserving muscle mass and maintaining adequate nutrition during weight loss efforts