Due to their similar structures, both hCG and LH bind to the same LHCGR receptor on Leydig cells, but hCG does so with greater affinity, preferentially inducing cAMP and increasing intracellular Ca, upregulating genes that code steroidogenic enzymes
Easy flushing, a stinging sensation, and small, pus-filled pimples are other common signs of the condition, which is often confused with acne breakouts
Patients with pre-existing bowel disorders or diabetic gastroparesis, those taking concurrent medications that slow gut motility (such as opioids, tricyclic antidepressants, calcium channel blockers, iron supplements, or antipsychotics), and older adults may be at increased risk
Weeks 5 through 8: 5 mg once weekly
Clinical validation data 97% of the subjects experienced an increase in skin chromaticity value (ITA) within 2 hours after the first use