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What This Means for Future Treatment Although retrospective, this evidence highlights the strong potential benefit of GLP-1 RAs in MPNs and MDS

Retatrutide is not FDA-approved and is currently limited to clinical research trials

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While GLP-1s are generally well tolerated and offer numerous health benefits from weight loss and better glucose control to a lower risk of cardiovascular disease research suggests they could increase the risk of certain serious eye conditions

For diabetes, NICE recommends continuing treatment if HbA1c reduces by at least 11 mmol/mol (1.0%) and weight decreases by at least 3% at 6 months