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The 20.9% mean body weight reduction seen in SURMOUNT-1 at 72 weeks reflects tirzepatides direct receptor binding and metabolic effects, not secondary antioxidant support
PEPT1 transporter uptake
They primarily include O 2 , hydroxyl radical (OH), hydroperoxyl radical (HO), peroxyl radical (RO), alkoxyl radical (RO), carbonate radical (CO), and other free radicals, as well as non-radicals such as H 2 O 2 , O 3 , singlet oxygen ( 1 O), hypochlorous acid (HOCl), hypobromous acid (HOBr), lipid peroxides (LOOH), and hypothiocyanous acid (HOSCN) [37,38,39]
GPx is present in all cell compartments, including the cytosol, mitochondria, and peroxisomes
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