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Bespoke protocol by Dr Vicky Bu, London
For a long long time I finally found something that works and gave me peace of mind overnight
Cytosolic GSH increases because oxidative stress activates CBS and GCS increasing the flux through the GCS and GS reactions and simultaneously lowering the cytosolic cysteine concentration
In similar studies on breast cancer and human nasopharyngeal epidermoid carcinoma cells, authors reported that doxorubicin-loaded nanoparticles with FA functionalization showed improved off-targeting with enhanced cellular uptake in higher FA-expressing KB and 4T1 cells [247]
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