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Acknowledgments We thank the Siddhi Memorial Foundation in Bhaktapur for providing excellent facilities to undertake this study

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Affinity-based approaches using an immobilized or tagged peptide to pull binding partners from a tissue lysate, photoaffinity labelling with a photoactivatable derivative, or thermal proteome profiling all attempt to answer what the peptide binds

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It's the fuel for sirtuins the longevity proteins involved in DNA repair and cellular maintenance and for healthy mitochondria, the engines inside every cell

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