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The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018

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Injectable glutathione delivers higher blood concentrations and bypasses digestive breakdown, creating greater pharmacological effect and safety riskthis triggers classification as an unapproved drug requiring prescriber oversight

Weight loss can improve insulin sensitivity and reduce blood sugar levels, potentially decreasing the need for additional medications

Os autores ressaltam, porm, que os achados ainda so preliminares e dependem de novos estudos clnicos em humanos