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4.2 Lipid metabolism Recent studies have demonstrated that long-chain polyunsaturated fatty acids (LCPUFAs), particularly -3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are closely associated with the development and progression of abdominal aortic aneurysm (AAA) ( 4.3 Amino acid metabolism 4.3.1 Sulfur-containing amino acids Cysteine (Cys), methionine (Met), and their metabolic derivative homocysteine (Hcy) play important roles in the context of abdominal aortic aneurysm (AAA) ( 4.3.2 Tryptophan Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is upregulated in abdominal aortic aneurysm (AAA) tissues, with increased expression of key enzymes and metabolites ( 4.3.3 Taurine Taurine (Tau) exerts significant vasoprotective effects through its antioxidant activity, scavenging of oxidants such as hypochlorous acid (HClO), reduction of inflammatory cell infiltration, and inhibition of matrix metalloproteinase (MMP) activity ( 4.3.4 Glycine Glycine (Gly) plays an important role in antioxidant and anti-inflammatory processes by restoring glutathione synthesis, inhibiting reactive oxygen species (ROS) production, and suppressing NF-B activation, thereby alleviating vascular inflammation ( 4.3.5 Glutamine and glutamate Glutamine (Gln) serves as a critical substrate for cellular proliferation

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress

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They are both manmade versions of a natural protein called alpha-melanocyte stimulating hormone, or alpha-MSH

13% of Canadian households have at least one member on GLP-1s and 18% more are open to using a GLP-1 medication in the future