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In addition, it has been shown that SAG pretreatment significantly prevents CCl4-induced cytotoxicity, is protective in restoring mitochondrial autophagy, and attenuates fibrosis, collagen deposition, hepatocellular damage and organ dysfunction

doi: 10.3390/ijms24010799 40 JiXQianXLuoGYangWHuangWLeiZ

Proc Natl Acad Sci USA 104 : 1662116626

[3] Prolonged therapy can unmask or exacerbate benign prostatic hyperplasia, raise prostate-specific antigen, worsen untreated obstructive sleep apnoea and is associated in some observational studies with a small but controversial increase in cardiovascular events, underlining the necessity for baseline and periodic monitoring of PSA, lipids and cardiovascular risk factors

Here are some reasons behind the initial discomfort when embarking on B12 therapy: Detoxification The enhanced B12 levels empower your body to expel built-up toxins with more efficiency