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The finding that the loss of GS-E transport increased lipid hydroperoxides, , -unsaturated carbonyls, and glutathione-conjugates of 4HNE were consistent with our predictions from in vitro studies

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Amphipathic helices and membrane curvature

GLUTATHIONE IN ENDOPLASMIC RETICULUM In ER, glutathione exists mainly as oxidized glutathione (GSSG)

[7] By inhibiting Caspase-3, Epithalon might contribute to cellular longevity and reduced apoptosis, which may complement its regenerative potential, yet this hypothesis demands more comprehensive research for validation