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Presence of severe or multiple risk factors for venous or arterial thrombosis, including: Inherited or acquired predisposition to venous or arterial thrombosis, such as activated protein C resistance, antithrombin-III deficiency, protein C deficiency, protein S deficiency, and antiphospholipid antibodies (e.g., anticardiolipin antibodies or lupus anticoagulant)

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Radiat Oncol Investig 3:383386