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Blood monocytes differentiate into several types of macrophages: classically activated types (M1) are pro-inflammatory and anti-fibrogenic, whereas alternatively activated M2 types are anti-inflammatory, pro-fibrogenic, and induce M1 cell apoptosis through IL-10 (Kazankov et al., 2019)
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In particular, the activation of the KP induces apoptosis in T-cells, inhibition of NK cell function as well as increased differentiation of regulatory T cells [126]
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