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Retatrutide activates three distinct G-protein coupled receptors, triggering cAMP-mediated signaling that enhances postprandial insulin secretion, improves glucose-dependent nutrient sensing, and increases hepatic fatty acid oxidation

et al., Drug Des Devel Ther, 2015

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Although Tirzepatide is a useful medication for controlling type 2 diabetes and facilitating weight loss, it may cause back pain in some people as an adverse reaction