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Physiological reviews

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Particularly, the reduction of GLP-1 release over time has been an observed feature of T2DM development, as GLP-1 reduces glucagon secretion and hepatic gluconeogenesis while promoting insulin secretion, thereby effectively minimizing hyperglycemia [106]

These findings highlight the divergent pharmacokinetic profiles of Ipamorelin and CJC-1295, with Ipamorelin suggested to provide rapid, short-duration action and CJC-1295 prolonged stimulation of GH secretion, a distinction that may inform the temporal dynamics of their combined study