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One survey found that over 60% of medical providers offer B12-vitamin Shots to their patients
10.1016/j.ejphar.2019.01.030 106 SeverM.KlicekR.RadicB.BrcicL.ZoricicI.DrmicD.et al (2009)
Serious adverse effects are rarely reported, though the absence of large-scale human clinical trials means some uncertainty remains about long-term safety
Possible signs include jawline prominence, enlarged hands/feet, coarse facial features, and organ enlargement (rare and associated with long-term abuse)
Reported or proposed issue Long-term or repeated-cycle effects Evidence source No long-term human trial Known or theoretical
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