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If this signified reduced cellular energy generation, it would contradict the notion that the other enzymatic changes were favorable
J Neural Transm (Vienna) 2018;125:12731286.ArticlePubMed 21
Figure 2 2 Data of efficacy 2.1 Clinical trials: the SURPASS program The central clinical trial program designed to demonstrate the therapeutic effectiveness (in terms of GC and BW reduction), tolerability and safety of TZP in diabetic patients was the SURPASS program
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And importantly, skeletal muscle does not appear to have a functional GLP-1 receptor, meaning these molecular effects are being mediated through indirect signaling pathways that we do not yet fully understand
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