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doi: 10.5604/01.3001.0014.1548 51 HoGTheissAL

Moreover, we found that colistin-induced depolarization is sensitive to cyclosporin A, a potent inhibitor of mitochondrial cyclophilin D (CyPD), one of the components of the mPTP, whose expression and function are required for the onset of the permeability transition 49

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A practical compromise involves starting with every-other-day dosing and adjusting based on your response