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[5] Patients prescribed GLP-1 agonists often have type 2 diabetes or obesity, conditions independently associated with increased rates of osteoarthritis and other musculoskeletal disorders

Even if employers adopted a BMI threshold of 35 or greater, 13% (14.6 million) of adults under 65 covered by an employer plan would exceed this threshold

The search for safe and effective pharmacologic weight-loss agents began in the late 19th century with the discovery that sheep thyroidextract increased metabolic rate and induced significant weight loss

Combining alcohol with these medications may cause blood sugars to fall too fast, leading to fainting and dizziness

In clinical studies, hunger hormones rose over 200% after 12 weeks, with participants losing up to 25 lbs without muscle loss and 95% reporting reduced sugar cravings