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These numbers should not be interpreted as safe or effective doses in humans
However, in M.tb -infected immunocompromised mice, JHU083 showed reduced therapeutic efficacy [36]
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The phospholipid peroxidase glutathione peroxidase 4 (GPX4), a GSH-dependent lipid repair enzyme, can prevent the development of this process by eliminating lipid peroxides
Furthermore, GHK-Cu's potential mechanism might involve the facilitation of copper uptake by cells, which might then be utilized by intracellular copper-dependent enzymes or directly activate transcription factors
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