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This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits
Primary concerns include increased injection site reactions from multiple subcutaneous injections, difficulty attributing adverse effects to the correct agent, additional cost without proven benefit, and potential quality variability in compounded lipotropic products
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Using data from the World Health Organization, they performed a disproportionality analysis, which sought to determine whether there were more reports of suicidal ideation in people taking GLP-1 drugs than would be expected compared to other types of drugs that people with obesity are commonly prescribed, like metformin (13)
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