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Inhibition of System Xc- using sorafenib reduces cystine uptake and indirectly suppresses GPX4 activity by depleting GSH, thereby inducing ferroptosis (43)

For women, particularly postmenopausal patients with increased cardiovascular risk, this low-dose regimen could serve as a preventive metabolic therapycomplementing hormone optimization, nutrition, and exercise to extend healthspan and protect against heart disease, the leading cause of death in women

Despite the well-documented health benefits of glucosinolates and their hydrolysis products such as isothiocyanates, their bioavailability in humans remains a significant challenge