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184,185,186,187 Interactions with other pathways GLP-1 not only promotes the release of insulin but also enhances the response of pancreatic -cells to insulin through the PI3K/Akt pathway, thereby improving insulin signal transduction and increasing the sensitivity of peripheral tissues to insulin

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Warnings and Precautions 5.1 Hypersensitivity Reactions Hypersensitivity reactions, including angioedema, have been reported in patients treated with REPATHA