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As of 2025, a total of 81 clinical trials have been initiated in this area, with four of them having been withdrawn

FIGURE 1 3.2 FOXO4-DRI effectively improves vascular function in prematurely aging mice To further explore the role of FOXO4-DRI in aged mice, we constructed prematurely aging mouse model by administering D-galactose (200 mg/kg) intraperitoneally for 8 weeks

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People with certain heart or blood pressure conditions can also be at risk of fluid overload from the infusion

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