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Post-menopausal use, while off-label, is supported by mechanistic logic and substantial compounding-pharmacy clinical experience

Insulin syringes have low dead space to minimise waste of residual insulin

Because all animals store B12 in their livers, eating liver is an excellent, though not particularly popular, treatment for B12 deficiency

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Subsequent work has largely validated the hypothesis, ie, trials of hemodynamic interventions have yielded disappointing or deleterious results, 2-4 whereas trials with beta-blockers, mineralocorticoid receptor antagonists (MRAs), and neprilysin inhibitors supported a role for neurohormonal mechanisms