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It sheds light on the emerging knowledge regarding the peptides, their specific receptors on brain endothelial cells, the selection of drug payloads, the design of DSIP-CBBBP, mechanisms of brain entry, and the efficiency of delivery to the brain ( On the other hand, the lack of a significant anxiolytic effect with GABA treatment raises questions about its bioavailability or receptor interactions in the specific context of the EPM test, possibly due to differences in the route of administration, dosage, or the animal models specific pathology

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PMID 12814619

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Improved Survival After Resection of Liver and Lung Colorectal Metastases Compared to Resection of Liver-Only Metastases: A Study of 112 Patients with Limited Lung Metastatic Disease