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Tirzepatide can cause acute kidney injury, particularly with severe gastrointestinal symptoms causing dehydration

Without a companion program, its possible to end up with sarcopenic obesity and a higher body fat composition than before starting the meds up to 40% of weight loss can be muscle

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GLP-1 receptor agonists also increase intestinal fluid secretion through chloride channel activation, as described in preclinical and clinical motility studies

Harrison DJ et al