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Cholecalciferol is metabolized to its active form, calcitriol, which increases the body's absorption of calcium and phosphorus

6-month knee pain reduction correlated more strongly with weight loss (r=0.72) than direct drug effect

At that point, switching to 20mg vials (lasting 5 weeks at 4mg/week) or 30mg vials (lasting 7.5 weeks) makes more practical sense

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Recent studies have provided compelling evidence of the significance of the GLP-1R in the dorsomedial hypothalamus, hindbrain, and lateral septum for the effect of GLP-1RAs in reducing obesity, highlighting the complexity of the involved brain network [12]