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The Na + site is located ~10 away from the substrate cavity, towards the bottom cytoplasmic side of a separate, enclosed aqueous cavity with a volume of ~195 3
Both approaches have merit
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Furthermore, oxytocin, as well as high-molecular-weight substances such as cobrotoxin, reach the brain in greater amounts when administered intranasally than when administered intravenously [89, 90]
Doubling up within a short window creates overlapping GH pulses that don't enhance the response
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