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Diabetes 68 , 188197 (2019)

reducing the risk of decreased glomerular filtration rate, end-stage renal disease, and cardiovascular mortality in patients with diabetes mellitus and chronic kidney disease

SESN2 exhibits antioxidative and autophagy-enhancing effects, protects cells from harmful stimuli, and plays a protective role in treating diseases associated with glucose and lipid metabolism 36

Secondary prevention: Reducing the risk of recurrent ASCVD events in individuals with established atherosclerotic cardiovascular disease