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In the linear mixed effects model, mean weight change at 6 months was 2.9 kg (95% CI, 4.1 to 1.7) and at 12 months was 4.2 kg (95% CI, 5.5 to 2.9)

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A consistent protocol is important because building the carnitine pool in the muscle is a process spread over time (Wall et al

So understanding the biology alone didnt get us there, but it was absolutely necessary before we could move on to the next phase. Each new leap in understanding may not be prize-worthy in isolation, but with each one, the door cracked open wider, expanding the number of people who could benefit from GLP-1 and other gut-hormone-based treatments

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