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Proc Natl Acad Sci

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Androgen depletion causes AR gene and/or enhancer amplification, which renders AR more sensitive to lower levels of ligands, and induces somatic mutations that broaden ARs ligand-binding spectrum or turn antagonists into agonists [4, 26, 27]

Taken together, the list suggests something bigger than a handful of standout cities: American job growth is fragmenting away from the handful of metros that have dominated the conversation for a decade, and toward a much wider, much less predictable set of places

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