Afamelanotide (Scenesse, Clinuvel Pharmaceuticals) is a linear MC1R selective tridecapeptide, approved by the FDA on October 8, 2019, and by the EMA on December 22, 2014, exclusively for the treatment of erythropoietic protoporphyria (EPP) in adults
Just as putative roles for CREB, ATF-1, and -catenin remain to be examined in the cardiovascular actions of GLP-1(2836), future studies will be needed to elucidate the role of sAC in the biological actions of GLP-1(2836) reported in hepatocytes and cells
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