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When tretinoin and niacinamide are combined into a single compounded formulation, the synergistic effects can offer multiple benefits for the skin for example: reduced skin irritation, enhanced efficacy, a simplified skin care routine and a more affordable treatment option

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The scalp is actually a reasonably permeable surface compared to other skin areas, especially when you use a vehicle (the carrier liquid) designed for skin penetration

[PMID: 10932736] PubMed record related to this compound for laboratory literature review