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The Lack of Fit value, representing the discrepancy between the model and the observed data, is determined to be not significant with a p-value of 0.1142

There is insufficient evidence to suggest that nucleoside analogs used in the treatment of HIV infection (i.e., zidovudine [AZT], didanosine [ddI], zalcitabine [ddC], and stavudine [d4T] or certain cancer chemotherapy agents (i.e., ifosfamide, cisplatin) increase the risk of secondary L-carnitine deficiency (135)

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Patients may still struggle with hard-to-lose fat in areas like the lower abdomen and hips

At the ASGCT 2025 meeting, Fractyl presented data showing low systemic circulating GLP-1 levels with their approach