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showed that exposure to nickel chloride in vitro induced lytic cell death and eryptosis, which is mediated by Ca 2+ influx and p38 MAPK signaling

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The expression of nutrient transporters, such as GLUT1 and LAT1, has been shown to be high in both, the BBB and in glioma (207, 208), which led to the development of different transporter-utilizing anti-cancer drug delivery strategies in order to reach the cancer cells residing beyond the intact BBB (Table II)

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"For all their promise, GLP-1 agonists have raised more questions than they have answered a hallmark of a true breakthrough," wrote Holden Thorp, Science journals' editor-in-chief, in an Editorial in the latest issue of Science