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GIP is another gut hormone involved in how the body handles blood sugar and fat, and engaging both pathways at once appears to give tirzepatide an added metabolic effect
Bioorg Med Chem Lett 14:58735876 Lv M, Xue G, Cheng H, Meng P, Lian X, Hlscher C, Li D (2021) The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-B inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01
Smits MM et al
The TRIUMPH-4 data answered that definitively
For GLP-1 weight loss medications, this can vary depending on the specific formulation
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