Large meta-analyses have clearly shown that during weight loss, increasing one's protein intake helps preserve muscle mass ( Kokura et al., 2024 )
Prokinetic agents like metoclopramide can help by speeding up gastric emptying, directly counteracting the semaglutide-induced delay
While semaglutide acts on the GLP-1 receptors which are primarily involved in glucose metabolism and appetite regulation, the comprehensive effects of this medication on other endocrine functions, including thyroid hormone synthesis and secretion, are not fully understood
GLP-/GIPR dual agonists have fewer side effects and greater safety, which means that the combination therapy has greater metabolic benefits than single use
Lack of an increase in fetal growth or insulin secretion from IGF-1 LR3 treatment in this study further supports the fact that a multipronged approach combining nutrient supplements with anabolic growth factors and oxygen is likely necessary, especially to support glucose oxidation and insulin secretion in the setting of placental insufficiency (50)