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Glutathione may be depleted by chronic inflammation, ongoing immune activation, elevated toxic body burden, and high levels of oxidative damage

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Nature (1997) 389(6651):6104.10.1038/39335 95 GagnonJSauvMZhaoWStaceyHMWiberSCBolzSSet alChronic exposure to TNFalpha impairs secretion of glucagon-like peptide-1

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Glutathione is often referred to as the master antioxidant because it helps regenerate other antioxidants, like Vitamin C and E, while also playing a central role in liver detoxification, cellular repair, and immune system function