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In 1967, Luzzatto 12 postulated at least two sites of union of the NADP to the enzyme, with a condition of transition from low to high affinity when NADPs concentration increases, which means that there exist two possible forms of the enzyme, according to its affinity by the NADP

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Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L

224,235 Currently, no specific inhibitors of the hexosamine pathway have been clinically validated to slow DPN progression, underscoring the need for novel therapeutic agents