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Unresolved hypotheses: mechanistic proposals that remain plausible but have not been directly demonstrated in the relevant AOD9604 metabolic model
This review highlights that NAD+ levels decline with age and play a critical role in metabolic and cellular health, with supplementation shown to raise NAD+ levels and potentially combat aspects of age-related decline
This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored
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