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Cytochrome P450 monooxygenases (P450) and carboxylesterases (CarEs) belong to phase I metabolizing enzymes that catalyze xenobiotics and endobiotics mainly through hydroxylation/oxidation reactions ( in situ selectivity in hydroxylation, epoxidation, dealkylation, sulfoxydation, deamination, desulphuration, dehalogenation, and nitro reduction (Xu et al., 2005)
This ensures researchers receive compounds that meet their specifications and support reliable experimental results
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Rotate injection sites when dosing twice weekly
Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, et al
