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A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets

Vomiting, diarrhea, and constipation also occur with meaningful frequency

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No study has compared injecting near an injury against injecting elsewhere for these compounds "inject near the injury" is a reasonable, low-cost default, but it is practitioner convention, not an evidence-backed advantage

In animal models, it has accelerated wound closure and increased new blood vessel formation in injured skin