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Human studies administering hexarelin multiple times daily or daily over several weeks have documented a progressive blunting of the GH response, consistent with GHSR-1a downregulation and desensitization

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Despite the broad parameter space, the qualitative dynamics remained largely unaffected, where key features such as exact adaptation and adaptation of the pulsatile activity were maintained (Appendix Fig S2, Appendix Table S1)

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Available from: NICE [Internet]