SURMOUNT-1 data: 2.5 mg tirzepatide: 8.1% headache rate 5 mg: 9.4% 10 mg: 10.2% 15 mg: 10.9% The increase is not dramatic, but the pattern is consistent
these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1
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This article aims to help primary care clinicians, who may not routinely have access to dermoscopy and biopsy, to identify possible NMSC lesions, which require further specialist assessment or monitoring
This increased training load, combined with reduced caloric intake, creates prime conditions for overuse injuries