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In PIONEER 6, over a median follow-up of 15.9 months, the composite primary endpoint of MACE was reported in 3.8% of patients in the oral semaglutide group vs

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3.5.2 GLP-1 modulation within reward networks and downregulation of motivation The reward network can be conceptualised as a distributed circuit involving the ACC, OFC, ventral striatum, ventral pallidum, and midbrain dopaminergic systems, with additional modulation by structures such as the amygdala and hippocampus (54, 55)

While frequently distressing for the patient, this specific olfactory manifestation is usually a benign physiological consequence of hepatic metabolism adapting to high concentrations of specific exogenous compounds

2020;180(3):585600 e19