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Phentermine is a Schedule IV controlled substance with some potential for dependence

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It also examines the expression of early-response genes in brain regions and the activity of biosynthetic and proteolytic processes

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Dosage may be reduced to 0.5 mL weekly in patients experiencing gastrointestinal intolerance or increased to a maximum of 2 mL twice weekly for short-term metabolic intensification when supervised by a qualified clinician