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IR and insulin signaling pathways IR is defined as the loss of the ability of target tissues to respond to insulin signals, resulting in hyperinsulinemia and associated with many metabolic disorders in MDS, such as obesity, MASLD and hypertension

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But the effectiveness of glutathione for skin lightening depends on several factors, including skin types, existing pigmentation, dosage, method of administration, lifestyle factors, and individual skin biology

Global IGF-I/IGF-IR double KO mice phenocopy the phenotypes of the global IGF-IR KO mice (28)

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